AsthmaĭUPIXENT is indicated as an add-on maintenance treatment of adult and pediatric patients aged 6 years and older with moderate-to-severe asthma characterized by an eosinophilic phenotype or with oral corticosteroid dependent asthma. DUPIXENT can be used with or without topical corticosteroids. Each pre-filled syringe delivers 300 mg dupilumab in 2 mL which also contains L-arginine hydrochloride (10.5 mg), L- histidine (6.2 mg), polysorbate 80 (4 mg), sodium acetate (2 mg), sucrose (100 mg), and water for injection, pH 5.9.ĭUPIXENT is indicated for the treatment of adult and pediatric patients aged 6 years and older with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. The needle cap is not made with natural rubber latex. DUPIXENT is provided as a single-dose pre-filled syringe with needle shield in a 2.25 mL siliconized Type-1 clear glass syringe. Dupilumab has an approximate molecular weight of 147 kDa.ĭupilumab is produced by recombinant DNA technology in Chinese Hamster Ovary cell suspension culture.ĭUPIXENT (dupilumab) Injection is supplied as a sterile, preservative-free, clear to slightly opalescent, colorless to pale yellow solution for subcutaneous injection. DESCRIPTIONĭupilumab, an interleukin-4 receptor alpha antagonist, is a human monoclonal antibody of the IgG4 subclass that binds to the IL-4Rα subunit and inhibits IL-4 and IL-13 signaling. You may report side effects to FDA at 1-80. For more information, ask your doctor or pharmacist.Ĭall your doctor for medical advice about side effects. These are not all the possible side effects of Dupixent. Tell the doctor if you have any side effect that bothers you or that does not go away. other herpes simplex virus infection, and.inflammation of the cornea ( keratitis),.The most common side effects of Dupixent include: Get medical help right away, if you have any of the symptoms listed above. outward eyelid rotation (cicatrical extropion).What are the possible side effects of Dupixent?ĭupixent may cause serious side effects including: It is not known if Dupixent is safe and effective in children younger than 6 years of age. In total, the company is connected to 4 other companies through its directors.Find Lowest Prices on What is Dupixent and how is it used?ĭupixent (dupilumab) injection is aninterleukin-4 receptor alpha- antagonist indicated for the treatment of patients with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable as an add-on maintenance treatment of adult and pediatric patients aged 6 years and older with moderate-to-severe asthma characterized by an eosinophilic phenotype or with oral corticosteroid dependent asthma as an add-on maintenance treatment in adult patients with inadequately controlled chronic rhinosinusitis with nasal polyposis (CRSwNP), and for the treatment of adult and pediatric patients aged 12 years and older, weighing at least 40 kg, with eosinophilic esophagitis (EoE).ĭupixent belongs to a class of drugs called Interleukin Inhibitors. The most recently appointed director is Deepak Mirza, who was appointed on 25 September, 2004.ĭeepak Mirza has the largest number of other directorships with a seat at a total of 5 companies. Natarajan Sankaranarayanan has been on the board for more than 17 years. The longest serving director currently on board is Natarajan Sankaranarayanan who was appointed on 10 September, 2004. The company has 2 directors and no reported key management personnel. Were the last known directors of the company.
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